In this study microcrystalline cellulose, coded MCC-MA was obtained from the processed stem of Momordica augustisepala. This extraction was effected by a two stage sodium hydroxide delignification process followed by a beaching process using laboratory prepared sodium hypochlorite. The product was examined for its physicochemical properties, flow characteristics and swelling parameters in comparison with Avicel, after which it was used as a disintegrant at various concentrations for the production of paracetamol tablets. The tablets were subsequently subjected to tablet quality testing procedure. The extraction yield of alpha cellulose from the sponge was approximately 56% and that of MCC-MA from the alpha cellulose approximately 77%. Results obtained from physicochemical tests showed a true density of 2.0lg/ml and a moisture content of 6.87%. The hydration and moisture sorption capacities were 3.24 and 13% respectively. The flow indices (angle of repose-37.25o, Carr’s index- 12.26%, Hausner’s index-1.14) showed that MCC-MA had good flow properties. Tablets produced with MCC-MA showed reasonable resistance to abrasion, excellent disintegration and tablet weight uniformity conforming to specified standards in the British and United State pharmacopoeia. Generally there was no significant difference (P>0.05) in the friability and disintegration time of tablets produced with Avicel and MCC-MA. However, there was significant difference (P<0.05) in the hardness and dissolution profile of tablets produced with both Avicel and MCC-MA. Tablets made with MCC-MA were less friable but have higher dissolution rate than those produced with Avicel.
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